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Factors Associated with the Progression of Preeclampsia at Kinshasa University Clinics in Democratic Republic of Congo

Received: 6 August 2020     Accepted: 24 August 2020     Published: 25 September 2020
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Abstract

Background and aims: the progression of preeclampsia continues to increase in sub-Saharan Africa where care is inadequate. The objective of this study is to identify factors associated with the progression of preeclampsia at University Clinics of Kinshasa. Methods: This is a prospective and analytical study of 265 patients hospitalized at the Gynecology Service of the University Clinics of Kinshasa between January 1, 2006 and December 31, 2015. The clinical, biological, therapeutic and evolutionary characteristics were the parameters of 'interest. Cox regression in multivariate analyzes was generated to identify risk factors for progression to the p <0.05 threshold. Results: The cumulative frequency of preeclapse decreased from 6.0% in the first year to 64.2% at the end of the study with periods of stagnation in the rate. Predictors of the progression of preeclampsia in the study population for F values equal to 2.86, 2.10, 3.57, 3.23, 2.81 and 0.005 and an α risk equal at 0.009; 0.014; 0.006; 0.007; 0.005 and 0.006 0.0005, respectively, for age, level of education, occupation, SAP, DBP and figure 3, led us to reject the null hypothesis of equality of means between progression and the lack of progression. In multiple cox regression, the risk of progression of preeclampsia was 3 times respectively in parturients aged > 35 years (aRR: 2.57 95% CI: 1.89-4.75), in female employees (aRR: 2.83 95% CI: 1.97-4.46); this risk was 2 times respectively among academics, PAS and PAD elevated. Treatment under scheme 3, on the other hand, reduced the risk of progression 2 (aRR: 0.43 95% CI: 0.28-0.63). Conclusion: the progression of pre-eclampsia could be linked to certain socio-demographic and clinical factors. The role played by the treatment regimen of αmethyl Dopa + Nifedipine + Diazepam remains to be defined in this subgroup.

Published in European Journal of Preventive Medicine (Volume 8, Issue 5)
DOI 10.11648/j.ejpm.20200805.12
Page(s) 66-71
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Progression, Preeclampsia, Risk Factors, CUK

References
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    Vangu Vangu Roland, Rahma Rashid Tozin, Mbuyi Muamba Jean Marie, Mokondjimobe Etienne, Mambueni Thamba Christophe, et al. (2020). Factors Associated with the Progression of Preeclampsia at Kinshasa University Clinics in Democratic Republic of Congo. European Journal of Preventive Medicine, 8(5), 66-71. https://doi.org/10.11648/j.ejpm.20200805.12

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    ACS Style

    Vangu Vangu Roland; Rahma Rashid Tozin; Mbuyi Muamba Jean Marie; Mokondjimobe Etienne; Mambueni Thamba Christophe, et al. Factors Associated with the Progression of Preeclampsia at Kinshasa University Clinics in Democratic Republic of Congo. Eur. J. Prev. Med. 2020, 8(5), 66-71. doi: 10.11648/j.ejpm.20200805.12

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    AMA Style

    Vangu Vangu Roland, Rahma Rashid Tozin, Mbuyi Muamba Jean Marie, Mokondjimobe Etienne, Mambueni Thamba Christophe, et al. Factors Associated with the Progression of Preeclampsia at Kinshasa University Clinics in Democratic Republic of Congo. Eur J Prev Med. 2020;8(5):66-71. doi: 10.11648/j.ejpm.20200805.12

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  • @article{10.11648/j.ejpm.20200805.12,
      author = {Vangu Vangu Roland and Rahma Rashid Tozin and Mbuyi Muamba Jean Marie and Mokondjimobe Etienne and Mambueni Thamba Christophe and Vangu Ngoma Dieudonné and Tsimba Vangu Andrien and Makoso Nimi Blaise and Mbungu Fuele Simon and Nkodila Natuhoyila Aliocha and Longo-Mbenza Benjamin},
      title = {Factors Associated with the Progression of Preeclampsia at Kinshasa University Clinics in Democratic Republic of Congo},
      journal = {European Journal of Preventive Medicine},
      volume = {8},
      number = {5},
      pages = {66-71},
      doi = {10.11648/j.ejpm.20200805.12},
      url = {https://doi.org/10.11648/j.ejpm.20200805.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20200805.12},
      abstract = {Background and aims: the progression of preeclampsia continues to increase in sub-Saharan Africa where care is inadequate. The objective of this study is to identify factors associated with the progression of preeclampsia at University Clinics of Kinshasa. Methods: This is a prospective and analytical study of 265 patients hospitalized at the Gynecology Service of the University Clinics of Kinshasa between January 1, 2006 and December 31, 2015. The clinical, biological, therapeutic and evolutionary characteristics were the parameters of 'interest. Cox regression in multivariate analyzes was generated to identify risk factors for progression to the p  35 years (aRR: 2.57 95% CI: 1.89-4.75), in female employees (aRR: 2.83 95% CI: 1.97-4.46); this risk was 2 times respectively among academics, PAS and PAD elevated. Treatment under scheme 3, on the other hand, reduced the risk of progression 2 (aRR: 0.43 95% CI: 0.28-0.63). Conclusion: the progression of pre-eclampsia could be linked to certain socio-demographic and clinical factors. The role played by the treatment regimen of αmethyl Dopa + Nifedipine + Diazepam remains to be defined in this subgroup.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Factors Associated with the Progression of Preeclampsia at Kinshasa University Clinics in Democratic Republic of Congo
    AU  - Vangu Vangu Roland
    AU  - Rahma Rashid Tozin
    AU  - Mbuyi Muamba Jean Marie
    AU  - Mokondjimobe Etienne
    AU  - Mambueni Thamba Christophe
    AU  - Vangu Ngoma Dieudonné
    AU  - Tsimba Vangu Andrien
    AU  - Makoso Nimi Blaise
    AU  - Mbungu Fuele Simon
    AU  - Nkodila Natuhoyila Aliocha
    AU  - Longo-Mbenza Benjamin
    Y1  - 2020/09/25
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ejpm.20200805.12
    DO  - 10.11648/j.ejpm.20200805.12
    T2  - European Journal of Preventive Medicine
    JF  - European Journal of Preventive Medicine
    JO  - European Journal of Preventive Medicine
    SP  - 66
    EP  - 71
    PB  - Science Publishing Group
    SN  - 2330-8230
    UR  - https://doi.org/10.11648/j.ejpm.20200805.12
    AB  - Background and aims: the progression of preeclampsia continues to increase in sub-Saharan Africa where care is inadequate. The objective of this study is to identify factors associated with the progression of preeclampsia at University Clinics of Kinshasa. Methods: This is a prospective and analytical study of 265 patients hospitalized at the Gynecology Service of the University Clinics of Kinshasa between January 1, 2006 and December 31, 2015. The clinical, biological, therapeutic and evolutionary characteristics were the parameters of 'interest. Cox regression in multivariate analyzes was generated to identify risk factors for progression to the p  35 years (aRR: 2.57 95% CI: 1.89-4.75), in female employees (aRR: 2.83 95% CI: 1.97-4.46); this risk was 2 times respectively among academics, PAS and PAD elevated. Treatment under scheme 3, on the other hand, reduced the risk of progression 2 (aRR: 0.43 95% CI: 0.28-0.63). Conclusion: the progression of pre-eclampsia could be linked to certain socio-demographic and clinical factors. The role played by the treatment regimen of αmethyl Dopa + Nifedipine + Diazepam remains to be defined in this subgroup.
    VL  - 8
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    ER  - 

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Author Information
  • Départment of Gynécology and Obstétric, University of Kinshasa, Kinshasa, Democratic Republic of Congo

  • Départment of Gynécology and Obstétric, University of Kinshasa, Kinshasa, Democratic Republic of Congo

  • Départment of Gynécology and Obstétric, University of Kinshasa, Kinshasa, Democratic Republic of Congo

  • Department of Public Health, Lomo-University Reseach, Kinshasa, Democratic Republic of Congo

  • Department of Public Health, Lomo-University Reseach, Kinshasa, Democratic Republic of Congo

  • Department of Public Health, Lomo-University Reseach, Kinshasa, Democratic Republic of Congo

  • Department of Internal Medecine, University of Président Joseph KASA-VUBU, Boma, Democratic Republic of Congo

  • Department of Internal Medecine, University of Président Joseph KASA-VUBU, Boma, Democratic Republic of Congo

  • Department of Public Health, Lomo-University Reseach, Kinshasa, Democratic Republic of Congo

  • Department of Public Health, Lomo-University Reseach, Kinshasa, Democratic Republic of Congo

  • Départment of Gynécology and Obstétric, University of Kinshasa, Kinshasa, Democratic Republic of Congo

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