Aim: Hepatitis B virus is a primary etiological factor for various liver diseases, including cirrhosis and hepatocellular carcinoma.Hepatitis B virus is an incomplete double-stranded DNA virus, which infects hepatic cells, enters the nucleus to form a complete double-stranded DNA and products a series of functional proteins, then replicates and assembles to form a complete virus, which is released outside the cell. So far, the pathogenesis of hepatitis B virus is not clear. JNK signaling pathway is an important branch of MAPK pathway, which plays an important role in various physiological and pathological processes such as cell cycle, reproduction, apoptosis and cell stress. Study show JNK activation involves liver damage. Especially, hepatitis B virus infection promote the phosphorylation of JNK. Chlorogenic acid, as a polyphenolic compound, exhibits notable antioxidant and antiviral properties. Study revealed chlorogenic acid had ability of inhibiting hepatitis B virus replication, but the mechanisms was unknown. Here we demonstrated the antiviral mechanisms of chlorogenic acd on HBV replication. Methods: To investigate the effect of chlorogenic acid on HBV replication, southern blot and western blot were performed using HepAD38 cells. Results: Chlorogenic acid suppressed HBV replication. In this process, JNK expression was inhibited. Conclusion: chlorogenic acid suppressed HBV replication via inhibiting JNK expression.
| Published in | Clinical Medicine Research (Volume 13, Issue 5) |
| DOI | 10.11648/j.cmr.20241305.11 |
| Page(s) | 55-59 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Chlorogenic Acid, HBV, JNK
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APA Style
Lai, L., Li, L., Cui, X., Piao, L., Cui, Z. (2024). Chlorogenic Acid Inhibition HBV Replication by Suppressed JNK Expression. Clinical Medicine Research, 13(5), 55-59. https://doi.org/10.11648/j.cmr.20241305.11
ACS Style
Lai, L.; Li, L.; Cui, X.; Piao, L.; Cui, Z. Chlorogenic Acid Inhibition HBV Replication by Suppressed JNK Expression. Clin. Med. Res. 2024, 13(5), 55-59. doi: 10.11648/j.cmr.20241305.11
AMA Style
Lai L, Li L, Cui X, Piao L, Cui Z. Chlorogenic Acid Inhibition HBV Replication by Suppressed JNK Expression. Clin Med Res. 2024;13(5):55-59. doi: 10.11648/j.cmr.20241305.11
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Download@article{10.11648/j.cmr.20241305.11,
author = {Lan Lai and Lihua Li and Xiuji Cui and Linghua Piao and Zhigang Cui},
title = {Chlorogenic Acid Inhibition HBV Replication by Suppressed JNK Expression
},
journal = {Clinical Medicine Research},
volume = {13},
number = {5},
pages = {55-59},
doi = {10.11648/j.cmr.20241305.11},
url = {https://doi.org/10.11648/j.cmr.20241305.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20241305.11},
abstract = {Aim: Hepatitis B virus is a primary etiological factor for various liver diseases, including cirrhosis and hepatocellular carcinoma.Hepatitis B virus is an incomplete double-stranded DNA virus, which infects hepatic cells, enters the nucleus to form a complete double-stranded DNA and products a series of functional proteins, then replicates and assembles to form a complete virus, which is released outside the cell. So far, the pathogenesis of hepatitis B virus is not clear. JNK signaling pathway is an important branch of MAPK pathway, which plays an important role in various physiological and pathological processes such as cell cycle, reproduction, apoptosis and cell stress. Study show JNK activation involves liver damage. Especially, hepatitis B virus infection promote the phosphorylation of JNK. Chlorogenic acid, as a polyphenolic compound, exhibits notable antioxidant and antiviral properties. Study revealed chlorogenic acid had ability of inhibiting hepatitis B virus replication, but the mechanisms was unknown. Here we demonstrated the antiviral mechanisms of chlorogenic acd on HBV replication. Methods: To investigate the effect of chlorogenic acid on HBV replication, southern blot and western blot were performed using HepAD38 cells. Results: Chlorogenic acid suppressed HBV replication. In this process, JNK expression was inhibited. Conclusion: chlorogenic acid suppressed HBV replication via inhibiting JNK expression.
},
year = {2024}
}
TY - JOUR T1 - Chlorogenic Acid Inhibition HBV Replication by Suppressed JNK Expression AU - Lan Lai AU - Lihua Li AU - Xiuji Cui AU - Linghua Piao AU - Zhigang Cui Y1 - 2024/09/20 PY - 2024 N1 - https://doi.org/10.11648/j.cmr.20241305.11 DO - 10.11648/j.cmr.20241305.11 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 55 EP - 59 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20241305.11 AB - Aim: Hepatitis B virus is a primary etiological factor for various liver diseases, including cirrhosis and hepatocellular carcinoma.Hepatitis B virus is an incomplete double-stranded DNA virus, which infects hepatic cells, enters the nucleus to form a complete double-stranded DNA and products a series of functional proteins, then replicates and assembles to form a complete virus, which is released outside the cell. So far, the pathogenesis of hepatitis B virus is not clear. JNK signaling pathway is an important branch of MAPK pathway, which plays an important role in various physiological and pathological processes such as cell cycle, reproduction, apoptosis and cell stress. Study show JNK activation involves liver damage. Especially, hepatitis B virus infection promote the phosphorylation of JNK. Chlorogenic acid, as a polyphenolic compound, exhibits notable antioxidant and antiviral properties. Study revealed chlorogenic acid had ability of inhibiting hepatitis B virus replication, but the mechanisms was unknown. Here we demonstrated the antiviral mechanisms of chlorogenic acd on HBV replication. Methods: To investigate the effect of chlorogenic acid on HBV replication, southern blot and western blot were performed using HepAD38 cells. Results: Chlorogenic acid suppressed HBV replication. In this process, JNK expression was inhibited. Conclusion: chlorogenic acid suppressed HBV replication via inhibiting JNK expression. VL - 13 IS - 5 ER -
Key Laboratory of Tropic Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou City, China
Key Laboratory of Tropic Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou City, China
Key Laboratory of Tropic Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou City, China
Key Laboratory of Tropic Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou City, China
Key Laboratory of Tropic Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou City, China
